Article
Construction of a multiplex allele-specific PCR-based universal array (ASPUA) and its application to hearing loss screening.
Human mutation - 1 Feb 2008
Li Cai-Xia, Pan Qian, Guo Yong-Gang, Li Yan, Gao Hua-Fang, Zhang Di, Hu Hao, Xing Wan-Li, Mitchelson Keith, Xia Kun, Dai Pu, Cheng Jing
Abstract excerpt
We demonstrate a new method, using a universal array approach termed multiplex allele-specific PCR-based universal array (ASPUA), and applied it to the mutation detection of hereditary hearing loss. Mutations in many different genes may be the cause of hereditary hearing loss, a sensory defect disorder. Effective methods for genetic diagnosis are clearly needed to provide clinical management. Owing to the broad...
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