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Visualization of Double-Stranded RNA in Cells Supporting Hepatitis C Virus RNA Replication

20 Dec 2007

Abstract excerpt

The mechanisms involved in hepatitis C virus (HCV) RNA replication are unknown, and this aspect of the virus life cycle is not understood. It is thought that virus-encoded nonstructural proteins and RNA genomes interact on rearranged endoplasmic reticulum (ER) membranes to form replication complexes, which are believed to be sites of RNA synthesis. We report that, through the use of an antibody specific for...

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Identifiers

PMID: 18094154
DOI: 10.1128/jvi.01565-07

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