Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Caenorhabditis elegans mboa-7, a member of the MBOAT family, is required for selective incorporation of polyunsaturated fatty acids into phosphatidylinositol.

Molecular biology of the cell - 1 Mar 2008

Lee Hyeon-Cheol, Inoue Takao, Imae Rieko, Kono Nozomu, Shirae Shinichiro, Matsuda Shinji, Gengyo-Ando Keiko, Mitani Shohei, Arai Hiroyuki

Abstract excerpt

Phosphatidylinositol (PI) is a component of membrane phospholipids, and it functions both as a signaling molecule and as a compartment-specific localization signal in the form of polyphosphoinositides. Arachidonic acid (AA) is the predominant fatty acid in the sn-2 position of PI in mammals. LysoPI acyltransferase (LPIAT) is thought to catalyze formation of AA-containing PI; however, the gene that encodes this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acyltransferases
Share to Arachidonic Acids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Caenorhabditis elegans

Share to Caenorhabditis elegans Proteins

Share to Fatty Acids, Unsaturated

Share to Genes, Helminth

Share to HeLa Cells

Share to Phosphatidylinositols

Source

Open in PubMed Open full text

Identifiers

PMID: 18094042
DOI: 10.1091/mbc.e07-09-0893
PMCID: PMC2262980

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Caenorhabditis elegans mboa-7, a member of the MBOAT family, is required for selective incorporation of polyunsaturated fatty acids into phosphatidylinositol.PMID 18094042Read ↗

Depletion of mboa-7, an enzyme that incorporates polyunsaturated fatty acids into phosphatidylinositol (PI), impairs PI 3-phosphate signaling in Caenorhabditis elegans.Semantic proximity Read ↗

LYCAT, a homologue of C. elegans acl-8,acl-9, and acl-10, determines the fatty acid composition of phosphatidylinositol in miceSemantic proximity Read ↗

Intracellular phospholipase A1 and acyltransferase, which are involved in Caenorhabditis elegans stem cell divisions, determine the sn-1 fatty acyl chain of phosphatidylinositol.Semantic proximity Read ↗

Suppression of the ELO-2 FA Elongation Activity Results in Alterations of the Fatty Acid Composition and Multiple Physiological Defects, Including Abnormal Ultradian Rhythms, in <i>Caenorhabditis elegans</i>Semantic proximity Read ↗

Tissue- and paralogue-specific functions of acyl-CoA-binding proteins in lipid metabolism in Caenorhabditis elegans.Semantic proximity Read ↗

Exploring Developmental and Physiological Functions of Fatty Acid and Lipid Variants Through Worm and Fly GeneticsSemantic proximity Read ↗

Contribution of sams-1 and pmt-1 to lipid homoeostasis in adult Caenorhabditis elegans.Semantic proximity Read ↗

Lipidomic and proteomic analysis of Caenorhabditis elegans lipid droplets and identification of ACS-4 as a lipid droplet-associated protein.Semantic proximity Read ↗

Specific polyunsaturated fatty acids drive TRPV-dependent sensory signaling in vivo.Semantic proximity Read ↗

The precursor of PI(3,4,5)P3 alleviates aging by activating daf-18(Pten) and independent of daf-16Semantic proximity Read ↗

The lipidomes of C. elegans with mutations in asm-3/acid sphingomyelinase and hyl-2/ceramide synthase show distinct lipid profiles during aging.Semantic proximity Read ↗

Mutations in MBOAT7, Encoding Lysophosphatidylinositol Acyltransferase I, Lead to Intellectual Disability Accompanied by Epilepsy and Autistic Features.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.