Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Consanguinity affects selection of alpha-thalassemia genotypes and the size of populations under selection pressure from malaria.

Annals of human biology - 1 Jan 2000

Denic Srdjan, Frampton Chris, Nagelkerke Nicolas, Nicholls M Gary

Abstract excerpt

BACKGROUND: In populations with alpha(+)-thalassemia gene deletion, the practice of consanguineous marriages is common. AIM: The study explored the impact of consanguinity (inbreeding) on the selection of alpha(+)-thalassemia genotypes in a computer model. METHOD: In a population under selection pressure from malaria, a single protective mutation (-alpha/alphaalpha genotype) was introduced among normal genotypes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-Thalassemia
Share to Computer Simulation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Consanguinity

Share to Genotype

Share to Homozygote

Share to Malaria

Share to Models, Genetic

Share to Selection, Genetic

Source

Identifiers

PMID: 18092206
DOI: 10.1080/03014460701615993

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Consanguinity affects selection of alpha-thalassemia genotypes and the size of populations under selection pressure from malaria.PMID 18092206Read ↗

Genetic benefits of consanguinity through selection of genotypes protective against malaria.Semantic proximity Read ↗

Evolutionary applications of population genetics with a focus on malaria : a computational approachSemantic proximity Read ↗

Understanding the contrasting spatial haplotype patterns of malaria-protective β-globin polymorphisms.Semantic proximity Read ↗

Natural selection of hemi- and heterozygotes for G6PD deficiency in Africa by resistance to severe malaria.Semantic proximity Read ↗

The effect on the equilibrium sickle cell allele frequency of the probable protection conferred by malaria and sickle cell gene against other infectious diseases.Semantic proximity Read ↗

Loss of balancing selection in the betaS globin locus.Semantic proximity Read ↗

Population dynamics with and without selection.Semantic proximity Read ↗

Incestuous gene in consanguinophilia and incest: toward a consilience theory of incest taboo.Semantic proximity Read ↗

Negative epistasis between the malaria-protective effects of α+-thalassemia and the sickle cell traitSemantic proximity Read ↗

Minimizing inbreeding by managing genetic contributions across generations.Semantic proximity Read ↗

Increased Microerythrocyte Count in Homozygous α+-Thalassaemia Contributes to Protection against Severe Malarial AnaemiaSemantic proximity Read ↗

Sickle haemoglobin, haemoglobin C and malaria mortality feedbacks.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.