Deriving structure from evolution: metazoan segmentation.

Abstract excerpt

Segmentation is a common feature of disparate clades of metazoans, and its evolution is a central problem of evolutionary developmental biology. We evolved in silico regulatory networks by a mutation/selection process that just rewards the number of segment boundaries. For segmentation controlled by a static gradient, as in long-germ band insects, a cascade of adjacent repressors reminiscent of gap genes evolves....

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