Article
Adaptation versus Selection: The Origins of Metastatic Behavior
15 Dec 2007
Abstract excerpt
During the formation of a primary tumor, premalignant cells acquire a series of genetic and epigenetic changes that enable them to proliferate in the absence of growth factors, to resist proapoptotic stimuli, and to stimulate angiogenesis (1). Each of these acquired traits confers a distinct selective advantage on those cells that develop it. In contrast, it is less clear how the initial steps of the...
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