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Article

The -1021 C/T DBH polymorphism is associated with neuropsychological performance among children and adolescents with ADHD.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jun 2008

Kieling Christian, Genro Júlia P, Hutz Mara H, Rohde Luis Augusto

Abstract excerpt

Catecholaminergic imbalance has increasingly been implicated in the pathophysiology of attention-deficit/hyperactivity disorder (ADHD). The enzyme dopamine-beta-hydroxylase (D beta H)-critical to catecholaminergic regulation-is under strong genetic control, with the -1021 C/T polymorphism accounting for up to 50% of the enzymatic activity. This work aimed to investigate association between this functional...

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Identifiers

PMID: 18081028
DOI: 10.1002/ajmg.b.30636

Genes

DBH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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