Article
Expression of the local angiotensin II system in gastric cancer may facilitate lymphatic invasion and nodal spread.
Cancer biology & therapy - 1 Aug 2007
Carl-McGrath Stacy, Ebert Matthias P A, Lendeckel Uwe, Röcken Christoph
Abstract excerpt
PURPOSE: In this study we investigated the putative pathophysiological mechanism, by which angiotensin converting enzyme (ACE), and angiotensin II receptor (ATR) type 1 and 2 might contribute to cancer progression and lymph node metastasis in gastric cancer. MATERIALS AND METHODS: Local expression of ACE, AT1R and AT2R was investigated immunohistochemically in non-lesional tissue, primary tumors and lymph node...
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