Article
The interleukin-1 and Fcgamma receptor gene polymorphisms in Japanese patients with rheumatoid arthritis and periodontitis.
Journal of periodontology - 1 Dec 2007
Kobayashi Tetsuo, Ito Satoshi, Kuroda Takeshi, Yamamoto Kouji, Sugita Noriko, Narita Ichiei, Sumida Takayuki, Gejyo Fumitake, Yoshie Hiromasa
Abstract excerpt
BACKGROUND: The pathobiology of rheumatoid arthritis (RA) is similar to that of periodontitis in that proinflammatory cytokines and immunoglobulin G Fc receptor (FcgammaR) play an important role. Functional polymorphisms of interleukin (IL)-1 and FcgammaR were shown to be associated with susceptibility to both diseases. Therefore, we evaluated whether the IL-1 and FcgammaR gene polymorphisms represent a common...
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