Article
Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked SNPs in the ANRIL locus on chromosome 9p.
Human molecular genetics - 15 Mar 2008
Broadbent Helen M, Peden John F, Lorkowski Stefan, Goel Anuj, Ongen Halit, Green Fiona, Clarke Robert, Collins Rory, Franzosi Maria Grazia, Tognoni Gianni, Seedorf Udo, Rust Stephan, Eriksson Per, Hamsten Anders, Farrall Martin, Watkins Hugh
Abstract excerpt
Genome-wide association studies have identified a region on chromosome 9p that is associated with coronary artery disease (CAD). The region is also associated with type 2 diabetes (T2D), a risk factor for CAD, although different SNPs were reported to be associated to each disease in separate studies. We have undertaken a case-control study in 4251 CAD cases and 4443 controls in four European populations using...
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