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Article

Human papillomaviruses activate caspases upon epithelial differentiation to induce viral genome amplification

28 Nov 2007

Abstract excerpt

The life cycle of human papillomaviruses (HPVs) is linked to epithelial differentiation, with late viral events restricted to the uppermost stratified layers. Our studies indicated that HPV activates capases-3, -7, and -9 upon differentiation, whereas minimal activation was observed in differentiating normal keratinocytes. Activation occurred in the absence of significant levels of apoptosis, suggesting a...

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PMID: 18048335
DOI: 10.1073/pnas.0707947104

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