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The human papillomavirus late life cycle and links to keratinocyte differentiation

1 Feb 2024

Abstract excerpt

Regulation of human papillomavirus (HPV) gene expression is tightly linked to differentiation of the keratinocytes the virus infects. HPV late gene expression is confined to the cells in the upper layers of the epithelium where the virus capsid proteins are synthesized. As these proteins are highly immunogenic, and the upper epithelium is an immune-privileged site, this spatial restriction aids immune evasion....

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PMID: 38345171
DOI: 10.1002/jmv.29461

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