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Cell Factors Stimulate Human Immunodeficiency Virus Type 1 Reverse Transcription In Vitro

29 Nov 2007

Abstract excerpt

After fusion of the human immunodeficiency virus type 1 (HIV-1) envelope with the host cell membrane, the HIV-1 core enters the cell cytoplasm. Core components are then restructured to form the reverse transcription complex (RTC); the biochemical details of this process are currently unclear. To investigate early RTC formation, we characterized the endogenous reverse transcription activity of virions, which was...

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PMID: 18045931
DOI: 10.1128/jvi.01808-07

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