Using protein complexes to predict phenotypic effects of gene mutation.

Abstract excerpt

BACKGROUND: Predicting the phenotypic effects of mutations is a central goal of genetics research; it has important applications in elucidating how genotype determines phenotype and in identifying human disease genes. RESULTS: Using a wide range of functional genomic data from the yeast Saccharomyces cerevisiae, we show that the best predictor of a protein's knockout phenotype is the knockout phenotype of other...

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