Article
No mutation was found in the alpha-subunit of the mitochondrial tri-functional protein in one patient with severe acute fatty liver of pregnancy and her relatives.
Journal of gastroenterology and hepatology - 1 Dec 2007
Kong Xiao-Fei, Zhang Xin-Xin, Yu Ying-Yan, Shi Qing, La Duan-Duan, Zhu-Ge Chuan-De, Deng Lin, Gong Qi-Ming, Shen Bai-Yong, Peng Cheng-Hong, Li Hong-Wei
Abstract excerpt
BACKGROUND AND AIM: Acute fatty liver of pregnancy (AFLP) is a serious hepatic disorder and a devastating late gestational complication associated with substantial maternal and neonatal morbidity and mortality. Several studies have demonstrated a strong association between AFLP in the mother and fetal deficiency of the enzyme long-chain L-3 hydroxyacyl-CoA dehydrogenase (LCHAD). LCHAD resides in the alpha-subunit...
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