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Article

Maternal heterozygosity for a mitochondrial trifunctional protein mutation as a cause for liver disease in pregnancy.

Medical hypotheses - 1 Jan 2005

Blish Kimberly R, Ibdah Jamal A

Abstract excerpt

Acute fatty liver of pregnancy (AFLP) and hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome are serious complications of pregnancy associated with significant maternal and perinatal morbidity and mortality. In previous reports, we have documented an association between AFLP and fetal deficiency of long-chain 3-hydroxyacyl coenzyme A dehydrogenase (LCHAD) [N. Engl. J. Med. 340 (1999) 1723-1731;...

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Source

Identifiers

PMID: 15533621
DOI: 10.1016/j.mehy.2004.06.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Maternal heterozygosity for a mitochondrial trifunctional protein mutation as a cause for liver disease in pregnancy.PMID 15533621Read ↗

A fetal fatty-acid oxidation disorder as a cause of liver disease in pregnant women.Semantic proximity Read ↗

Maternal acute fatty liver of pregnancy associated with fetal trifunctional protein deficiency: molecular characterization of a novel maternal mutant allele.Semantic proximity Read ↗

Prospective Screening for Pediatric Mitochondrial Trifunctional Protein Defects in Pregnancies Complicated by Liver DiseaseSemantic proximity Read ↗

Acute fatty liver of pregnancy associated with fetal mitochondrial trifunctional protein deficiency.Semantic proximity Read ↗

Fetal genotypes and pregnancy outcomes in 35 families with mitochondrial trifunctional protein mutations.Semantic proximity Read ↗

Liver disease in pregnancy and fetal fatty acid oxidation defects.Semantic proximity Read ↗

Molecular prenatal diagnosis in families with fetal mitochondrial trifunctional protein mutations.Semantic proximity Read ↗

No mutation was found in the alpha-subunit of the mitochondrial tri-functional protein in one patient with severe acute fatty liver of pregnancy and her relatives.Semantic proximity Read ↗

Neither maternal nor fetal mutation (E474Q) in the alpha-subunit of the trifunctional protein is frequent in pregnancies complicated by HELLP syndrome.Semantic proximity Read ↗

Mitochondrial Dysfunction and Acute Fatty Liver of PregnancySemantic proximity Read ↗

Acute fatty liver of pregnancy and neonatal long-chain 3-hydroxyacyl-coenzyme A dehydrogenase (LCHAD) deficiency.Semantic proximity Read ↗

Acute fatty liver disease of pregnancySemantic proximity Read ↗

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