Article
Liver disease in pregnancy and fetal fatty acid oxidation defects.
Molecular genetics and metabolism - 1 Jan 2000
Ibdah J A, Yang Z, Bennett M J
Abstract excerpt
Acute fatty liver of pregnancy (AFLP) and the syndrome of hemolysis, elevated liver enzymes, and low platelets (the HELLP syndrome) are serious disorders of the third trimester with high maternal and perinatal morbidity and mortality. Over the past decade, several clinical observations have demonstrated an association between these maternal syndromes and a recessively inherited fatty acid oxidation disorder, long...
Topics
- 3-Hydroxyacyl CoA Dehydrogenases
- Fatty Acids
- Fatty Liver
- Female
- Fetus
- HELLP Syndrome
- Humans
- Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase
- Maternal-Fetal Exchange
- Mitochondria, Liver
- Oxidation-Reduction