Article
A fetal fatty-acid oxidation disorder as a cause of liver disease in pregnant women.
The New England journal of medicine - 3 Jun 1999
Ibdah J A, Bennett M J, Rinaldo P, Zhao Y, Gibson B, Sims H F, Strauss A W
Abstract excerpt
BACKGROUND: Acute fatty liver of pregnancy and the HELLP syndrome (hemolysis, elevated liver-enzyme levels, and a low platelet count) are serious hepatic disorders that may occur during pregnancy in women whose fetuses are later found to have a deficiency of long-chain 3-hydroxyacyl-coenzyme A (CoA) dehydrogenase. This enzyme resides in the mitochondrial trifunctional protein, which also contains the active site...
Topics
- 3-Hydroxyacyl CoA Dehydrogenases
- Acute Disease
- DNA Mutational Analysis
- Fatty Acids
- Fatty Liver
- Female
- Fetal Diseases
- Genotype
- HELLP Syndrome
- Humans
- Infant