Article
External quality assessment of HLA-B*5701 reporting: an international multicentre survey.
Antiviral therapy - 1 Jan 2007
Hammond Emma, Almeida Coral-Ann, Mamotte Cyril, Nolan David, Phillips Elizabeth, Schollaardt Tineke Asma, Gill M John, Angel Jonathan B, Neurath Doris, Li Jianping, Giulivi Tony, McIntyre Cathy, Koultchitski Galina, Wong Betty, Reis Marciano, Rachlis Anita, Cole David E, Chew Choo Beng, Neifer Stefan, Lalonde Richard, Roger Michel, Jeanneau Annie, Mallal Simon
Abstract excerpt
OBJECTIVES: HLA-B*5701 strongly predicts abacavir hypersensitivity (HSR), but implementation of effective routine screening into clinical practice requires testing be practical and accurate. We tested the proficiency of HLA-B*5701 typing among laboratories using sequence-specific primer PCR. DESIGN AND METHODS: DNA panels (1 and 2) were distributed to seven laboratories (A to G) for blinded typing of the...
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