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Article

Defective Chromosome Segregation and Telomere Dysfunction in Aggressive Wilms' Tumors

15 Nov 2007

Abstract excerpt

PURPOSE: In many childhood neoplasms, prognostic subgroups have been defined based on specific chromosome changes. In Wilms' tumor (WT), such subclassification has been hampered by the diverse and relatively unspecific pattern of chromosomal imbalances present in these tumors. Unspecific patterns of cytogenetic imbalances in tumors are often caused by mitotic segregation errors due to short dysfunctional...

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Share to Microtubule and mitosis dynamics
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PMID: 18006759
DOI: 10.1158/1078-0432.ccr-07-1081

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