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Article

Combined BubR1 protein down-regulation and RASSF1A hypermethylation in Wilms tumors with diverse cytogenetic changes.

Molecular carcinogenesis - 1 Sept 2008

Haruta Masayuki, Matsumoto Yoshiyuki, Izumi Hideki, Watanabe Naoki, Fukuzawa Masahiro, Matsuura Shinya, Kaneko Yasuhiko

Abstract excerpt

BUB1B and RASSF1A genes play specific roles in the mitotic checkpoint, and their defects may cause chromosome instability or aneuploidy in mouse fibroblasts and human cancer cell lines; however, few studies have reported a correlation between defects in these genes and chromosome changes in human tumor samples. We examined chromosome abnormalities in 25 Wilms tumors by metaphase comparative genomic hybridization,...

Topics

Cell Cycle Proteins
Child
Child, Preschool
Chromosome Mapping
Diploidy
Down-Regulation
Gene Expression Regulation, Neoplastic
Humans
Infant
Methylation
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nucleic Acid Hybridization

Protein Serine-Threonine Kinases

Reverse Transcriptase Polymerase Chain Reaction

Tumor Suppressor Proteins

Wilms Tumor

Source

Identifiers

PMID: 18286482
DOI: 10.1002/mc.20412

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-18286482-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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