Article
A bioinformatic filter for improved base-call accuracy and polymorphism detection using the Affymetrix GeneChip whole-genome resequencing platform.
Nucleic acids research - 1 Jan 2007
Pandya Gagan A, Holmes Michael H, Sunkara Sirisha, Sparks Andrew, Bai Yun, Verratti Kathleen, Saeed Kelly, Venepally Pratap, Jarrahi Behnam, Fleischmann Robert D, Peterson Scott N
Abstract excerpt
DNA resequencing arrays enable rapid acquisition of high-quality sequence data. This technology represents a promising platform for rapid high-resolution genotyping of microorganisms. Traditional array-based resequencing methods have relied on the use of specific PCR-amplified fragments from the query samples as hybridization targets. While this specificity in the target DNA population reduces the potential for...
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