Article
High-density association study and nomination of susceptibility genes for hypertension in the Japanese National Project.
Human molecular genetics - 15 Feb 2008
Kato Norihiro, Miyata Toshiyuki, Tabara Yasuharu, Katsuya Tomohiro, Yanai Kazuyuki, Hanada Hironori, Kamide Kei, Nakura Jun, Kohara Katsuhiko, Takeuchi Fumihiko, Mano Hiroyuki, Yasunami Michio, Kimura Akinori, Kita Yoshikuni, Ueshima Hirotsugu, Nakayama Tomohiro, Soma Masayoshi, Hata Akira, Fujioka Akihiro, Kawano Yuhei, Nakao Kazuwa, Sekine Akihiro, Yoshida Teruhiko, Nakamura Yusuke, Saruta Takao, Ogihara Toshio, Sugano Sumio, Miki Tetsuro, Tomoike Hitonobu
Abstract excerpt
Essential hypertension is one of the most common, complex diseases, of which considerable efforts have been made to unravel the pathophysiological mechanisms. Over the last decade, multiple genome-wide linkage analyses have been conducted using 300-900 microsatellite markers but no single study has yielded definitive evidence for 'principal' hypertension susceptibility gene(s). Here, we performed a three-tiered,...
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