Article
Strong evidence that GNB1L is associated with schizophrenia.
Human molecular genetics - 15 Feb 2008
Williams Nigel M, Glaser Beate, Norton Nadine, Williams Hywel, Pierce Timothy, Moskvina Valentina, Monks Stephen, Del Favero Jurgen, Goossens Dirk, Rujescu Dan, Giegling Ina, Kirov George, Craddock Nicholas, Murphy Kieran C, O'Donovan Michael C, Owen Michael J
Abstract excerpt
Evidence that a gene or genes on chromosome 22 is involved in susceptibility to schizophrenia comes from two sources: the increased incidence of schizophrenia in individuals with 22q11 deletion syndrome (22q11DS) and genetic linkage studies. In mice, hemizygous deletion of either Tbx1 or Gnb1l can cause deficits in pre-pulse inhibition, a sensory motor gating defect which is associated with schizophrenia. We...
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