Genetics of sexual development: A new paradigm

Abstract excerpt

The classical paradigm of human and mammalian sexual development, largely based on work of Alfred Jost, depicts the genetic factor(s) that determine(s) sex as influencing only the fate of the gonad. A maleness factor produces testes (Primary Sex Determination). These organs secrete hormones which cause male Secondary Sexual Differentiation. In absence of the maleness factor, by default the gonad becomes an ovary,...

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• Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
• Share to Sexual Differentiation and Disorders
• Share to Sperm and Testicular Function