Article
Effectiveness of a program aimed at the elimination of BLAD-carrier bulls from Polish Holstein-Friesian cattle.
Journal of applied genetics - 1 Jan 2007
Czarnik Urszula, Grzybowski Grzegorz, Kamiński Stanisław, Prusak Beata, Zabolewicz Tadeusz
Abstract excerpt
The molecular basis of BLAD is the D128G mutation of the gene coding for the CD18 subunit of beta-2 integrin. This mutation is lethal, since homozygous (BL/BL) animals die before they reach sexual maturity. In the 1990s, BLAD was the most widespread genetic disease in HF cattle worldwide. The aim of the present study was to determine the frequency of BLAD carriers among 4645 young breeding bulls in Poland in...
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