Novel Protein Antigen (JHP940) from the Genomic Plasticity Region ofHelicobacter pyloriInduces Tumor Necrosis Factor Alpha and Interleukin-8 Secretion by Human Macrophages

Abstract excerpt

The plasticity region of the Helicobacter pylori genome comprises strain-specific gene loci. We performed genotyping and functional biology analysis of one such locus (jhp940) that was previously found to be functionally unknown but present in gastric cancer-associated strains from many different countries. We found its geographic prevalence to be independent of cagA presence and disease status. Cloning,...

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