Article
The Helicobacter pylori plasticity region locus jhp0947-jhp0949 is associated with duodenal ulcer disease and interleukin-12 production in monocyte cells.
FEMS immunology and medical microbiology - 1 Jun 2004
de Jonge Ramon, Kuipers Ernst J, Langeveld Sabine C L, Loffeld Ruud J L F, Stoof Jeroen, van Vliet Arnoud H M, Kusters Johannes G
Abstract excerpt
Colonization with Helicobacter pylori always results in chronic gastritis, which is controlled by infiltration of mononuclear cells and the subsequent release of cytokines like interleukin (IL)-12. To identify H. pylori factors involved in inducing cytokine production in mononuclear cells, a random H. pylori mutant library was screened for the inability to induce IL-12 production in monocyte THP-1 cells. Of the...
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