Article
Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilation.
Journal of applied physiology (Bethesda, Md. : 1985) - 1 Feb 2008
Sorkness Ronald L, Bleecker Eugene R, Busse William W, Calhoun William J, Castro Mario, Chung Kian Fan, Curran-Everett Douglas, Erzurum Serpil C, Gaston Benjamin M, Israel Elliot, Jarjour Nizar N, Moore Wendy C, Peters Stephen P, Teague W Gerald, Wenzel Sally E
Abstract excerpt
Five to ten percent of asthma cases are poorly controlled chronically and refractory to treatment, and these severe cases account for disproportionate asthma-associated morbidity, mortality, and health care utilization. While persons with severe asthma tend to have more airway obstruction, it is not known whether they represent the severe tail of a unimodal asthma population, or a severe asthma phenotype. We...
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