Article
Correlation between some Th1 and Th2 cytokine receptor gene polymorphisms and systemic lupus erythematosus in Chinese patients.
International journal of dermatology - 1 Nov 2007
Xu Yao, Chen Zhi-Qiang, Li Yu-Mei, Gong Juan-Qin, Li An-Sheng, Chen Min, Liu Jun
Abstract excerpt
BACKGROUND: Genetic factors seem to play a significant role in the susceptibility to systemic lupus erythematosus (SLE). Some researchers have described amino acid polymorphisms within the interleukin-4 receptor (IL-4R) [isoleucine50valine (Ile50Val), arginine576glutamine (Arg576Gln), etc.], the IL-10R (G241A and G520A), and the interferon-gamma receptor (IFN-gammaR) [valine14methionine (Val14Met) and...
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