Article
Somatostatin genetic variants modify the risk for Alzheimer's disease among Finnish patients.
Journal of neurology - 1 Nov 2007
Vepsäläinen Saila, Helisalmi Seppo, Koivisto Anne M, Tapaninen Toni, Hiltunen Mikko, Soininen Hilkka
Abstract excerpt
The levels of somatostatin are consistently decreased in the brain and cerebrospinal fluid of Alzheimer's disease (AD) patients. The somatostatin gene is located on chromosome 3q27.3 close to an association region identified in late-onset AD patients originating from Finland. Since somatostatin is a good candidate on both positional and functional grounds, we studied whether single nucleotide polymorphisms (SNPs)...
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