Increased Gs signalling in platelets and impaired collagen activation, due to a defect in the dystrophin gene, result in increased blood loss during spinal surgery.

doi:10.1093/hmg/ddm312

Article

Increased Gs signalling in platelets and impaired collagen activation, due to a defect in the dystrophin gene, result in increased blood loss during spinal surgery.

Human molecular genetics - 1 Feb 2008

Labarque Veerle, Freson Kathleen, Thys Chantal, Wittevrongel Christine, Hoylaerts Marc F, De Vos Rita, Goemans Nathalie, Van Geet Chris

Abstract excerpt

Controversy exists regarding the cause of the significantly increased blood loss during spinal surgery in Duchenne muscular dystrophy (DMD) patients compared with similar surgery in other patients. DMD is caused by a mutation in the cytoskeletal dystrophin, which binds to extracellular matrix laminin and which has been described as a G-protein-coupled receptor. We hypothesized that disturbed cytoskeleton...

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