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Article

Genetic polymorphisms associated with cigarette smoking and the risk of Graves' disease.

Clinical endocrinology - 1 Jun 2008

Bufalo Natássia E, Santos Roberto B, Cury Adriano N, Andrade Renato A, Morari Joseane, Morari Elaine C, Leite Janaína L, Monte Osmar, Romaldini João H, Ward Laura S

Abstract excerpt

OBJECTIVE: Cigarette smoking is a well-recognized risk factor of Graves' disease and, particularly, Graves' ophthalmopathy. Hence, germline polymorphisms of detoxification genes and genes belonging to the major DNA repair-apoptosis pathways might have an important role in disease susceptibility. In addition, as some of these genes are regulated by thyroid hormones, they may affect the patients' outcomes. We aimed...

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Source

Identifiers

PMID: 17980001
DOI: 10.1111/j.1365-2265.2007.03121.x

Genes

GSTP1
GSTM1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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