Article
Validating psychiatric endophenotypes: inhibitory control and attention deficit hyperactivity disorder.
Neuroscience and biobehavioral reviews - 1 Jan 2008
Crosbie Jennifer, Pérusse Daniel, Barr Cathy L, Schachar Russell J
Abstract excerpt
ADHD is a heritable condition of childhood for which several risk alleles have been identified. However, observed effect sizes have been small and few replicated polymorphisms have been identified. There are many reasons for the lack of one-to-one correspondence between genotype and phenotype in ADHD. Endophenotypes are non-clinical markers of genetic risk which may facilitate gene discovery in complex disorders...
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