Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Engineering modified Bt toxins to counter insect resistance.

Science (New York, N.Y.) - 7 Dec 2007

Soberón Mario, Pardo-López Liliana, López Idalia, Gómez Isabel, Tabashnik Bruce E, Bravo Alejandra

Abstract excerpt

The evolution of insect resistance threatens the effectiveness of Bacillus thuringiensis (Bt) toxins that are widely used in sprays and transgenic crops. Resistance to Bt toxins in some insects is linked with mutations that disrupt a toxin-binding cadherin protein. We show that susceptibility to the Bt toxin Cry1Ab was reduced by cadherin gene silencing with RNA interference in Manduca sexta, confirming...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacillus thuringiensis Toxins
Share to Endotoxins
Share to Genetic Engineering

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hemolysin Proteins

Share to Insecticide Resistance

Share to Manduca

Share to Pest Control, Biological

Source

Identifiers

PMID: 17975031
DOI: 10.1126/science.1146453

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Engineering modified Bt toxins to counter insect resistance.PMID 17975031Read ↗

Efficacy of genetically modified Bt toxins against insects with different genetic mechanisms of resistance.Semantic proximity Read ↗

Tobacco plants expressing the Cry1AbMod toxin suppress tolerance to Cry1Ab toxin of Manduca sexta cadherin-silenced larvae.Semantic proximity Read ↗

Bacillus thuringiensis insecticidal three-domain Cry toxins: mode of action, insect resistance and consequences for crop protection.Semantic proximity Read ↗

Bacillus thuringiensis Cry1Ab mutants affecting oligomer formation are non-toxic to Manduca sexta larvae.Semantic proximity Read ↗

Novel genetic basis of field-evolved resistance to Bt toxins in Plutella xylostella.Semantic proximity Read ↗

Cry1Aa binding to the cadherin receptor does not require conserved amino acid sequences in the domain II loops.Semantic proximity Read ↗

Continuous evolution of Bacillus thuringiensis toxins overcomes insect resistance.Semantic proximity Read ↗

Alternative splicing and highly variable cadherin transcripts associated with field-evolved resistance of pink bollworm to bt cotton in India.Semantic proximity Read ↗

Cadherin repeat 5 mutation associated with Bt resistance in a field-derived strain of pink bollworm.Semantic proximity Read ↗

Characterization of the mechanism of action of the genetically modified Cry1AbMod toxin that is active against Cry1Ab-resistant insects.Semantic proximity Read ↗

Single amino acid mutations in the cadherin receptor from Heliothis virescens affect its toxin binding ability to Cry1A toxins.Semantic proximity Read ↗

Bioengineering: Evolved to overcome Bt-toxin resistance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.