Article
Continuous evolution of Bacillus thuringiensis toxins overcomes insect resistance.
Nature - 5 May 2016
Badran Ahmed H, Guzov Victor M, Huai Qing, Kemp Melissa M, Vishwanath Prashanth, Kain Wendy, Nance Autumn M, Evdokimov Artem, Moshiri Farhad, Turner Keith H, Wang Ping, Malvar Thomas, Liu David R
Abstract excerpt
The Bacillus thuringiensis δ-endotoxins (Bt toxins) are widely used insecticidal proteins in engineered crops that provide agricultural, economic, and environmental benefits. The development of insect resistance to Bt toxins endangers their long-term effectiveness. Here we have developed a phage-assisted continuous evolution selection that rapidly evolves high-affinity protein-protein interactions, and applied...
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