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Gene Expression Analysis of Preinvasive and Invasive Cervical Squamous Cell Carcinomas Identifies <i>HOXC10</i> as a Key Mediator of Invasion

1 Nov 2007

Abstract excerpt

If left untreated, a subset of high-grade squamous intraepithelial lesions (HSIL) of the cervix will progress to invasive squamous cell carcinomas (SCC). To identify genes whose differential expression is linked to cervical cancer progression, we compared gene expression in microdissected squamous epithelial samples from 10 normal cervices, 7 HSILs, and 21 SCCs using high-density oligonucleotide microarrays. We...

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PMID: 17974957
DOI: 10.1158/0008-5472.can-07-2056

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