Article
Molecular analysis of a multistep lung cancer model induced by chronic inflammation reveals epigenetic regulation of p16 and activation of the DNA damage response pathway.
Neoplasia (New York, N.Y.) - 1 Oct 2007
Blanco David, Vicent Silvestre, Fraga Mario F, Fernandez-Garcia Ignacio, Freire Javier, Lujambio Amaia, Esteller Manel, Ortiz-de-Solorzano Carlos, Pio Ruben, Lecanda Fernando, Montuenga Luis M
Abstract excerpt
The molecular hallmarks of inflammation-mediated lung carcinogenesis have not been fully clarified, mainly due to the scarcity of appropriate animal models. We have used a silica-induced multistep lung carcinogenesis model driven by chronic inflammation to study the evolution of molecular markers and genetic alterations. We analyzed markers of DNA damage response (DDR), proliferative stress, and telomeric stress:...
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