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Article

Characterizations of a loss-of-function mutation in the Kir3.4 channel subunit.

Biochemical and biophysical research communications - 28 Dec 2007

Calloe Kirstine, Ravn Lasse Steen, Schmitt Nicole, Sui Jin Liang, Duno Morten, Haunso Stig, Grunnet Morten, Svendsen Jesper Hastrup, Olesen Soren-Peter

Abstract excerpt

Kir3.4 and Kir3.1 potassium channel subunits mediate the acetylcholine induced inwardly rectifying current I(KACh) in the heart. We found a glycine to arginine substitution in codon 247 of Kir3.4 in a patient with a single episode of atrial fibrillation (AF). Expression in Xenopus laevis oocytes and two-electrode voltage-clamp revealed that Kir3.4-G247R basal current was reduced compared to wild-type Kir3.4 and...

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Identifiers

PMID: 17967416
DOI: 10.1016/j.bbrc.2007.10.106

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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