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Article

A Kir2.1 gain-of-function mutation underlies familial atrial fibrillation.

Biochemical and biophysical research communications - 15 Jul 2005

Xia Min, Jin Qingfeng, Bendahhou Saïd, He Yusong, Larroque Marie-Madeleine, Chen Yiping, Zhou Qinshu, Yang Yiqing, Liu Yi, Liu Ban, Zhu Qian, Zhou Yanting, Lin Jie, Liang Bo, Li Li, Dong Xiongjian, Pan Zhiwen, Wang Rongrong, Wan Haiying, Qiu Weiqin, Xu Wenyuan, Eurlings Petra, Barhanin Jacques, Chen Yihan

Abstract excerpt

The inward rectifier K(+) channel Kir2.1 mediates the potassium I(K1) current in the heart. It is encoded by KCNJ2 gene that has been linked to Andersen's syndrome. Recently, strong evidences showed that Kir2.1 channels were associated with mouse atrial fibrillation (AF), therefore we hypothesize...

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Source

Identifiers

PMID: 15922306
DOI: 10.1016/j.bbrc.2005.05.054

Genes

KCNJ2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15922306-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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