Article
Why schizophrenia genetics needs epigenetics: a review.
Psychiatria Danubina - 1 Mar 2012
Maric Nadja P, Svrakic Dragan M
Abstract excerpt
Schizophrenia (SZ) is a highly heritable disorder, with about 80% of the variance attributable to genetic factors. There is accumulating evidence that both common genetic variants with small effects and rare genetic lesions with large effects determine risk of SZ. As recently shown, thousands of common single nucleotide polymorphisms (SNPs), each with small effect, cumulatively could explain about 30% of the...
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