Article
Polymorphism of glutathione S-transferase P1 gene affects human vitamin C metabolism.
Biochemical and biophysical research communications - 21 Dec 2007
Higasa Shizu, Tsujimura Masaru, Hiraoka Mami, Nakayama Kazuhiro, Yanagisawa Yoshiko, Iwamoto Sadahiko, Kagawa Yasuo
Abstract excerpt
There are large inter-individual differences in the metabolism of vitamin C (VC), which is composed of both ascorbic acid (AsA) and dehydroascorbic acid (DAsA). AsA is oxidized to DAsA in a series of xenobiotic reactions. Thus, the effects of polymorphism A313G (Ile105Val) in the gene for glutathione S-transferases P1 (GSTP1), one of the most active xenobiotic enzymes, on human VC metabolism were studied. The...
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