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Article

The microenvironment of human neuroblastoma supports the activation of tumor-associated T lymphocytes

1 Mar 2013

Abstract excerpt

Tumor infiltration by lymphocytes has been linked to improved clinical outcome in children with neuroblastoma (NB) but T-cell activation has never been demonstrated to occur within the NB microenvironment. Here we show that tumor-associated lymphocytes (TALs) obtained from lesions representing all genetic subsets of NB and autologous peripheral blood lymphocytes (PBLs) analyzed on the day of tumor excision...

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PMID: 23802089
DOI: 10.4161/onci.23618

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