Article
Potential histologic and molecular predictors of response to temsirolimus in patients with advanced renal cell carcinoma.
Clinical genitourinary cancer - 1 Sept 2007
Cho Daniel, Signoretti Sabina, Dabora Sandra, Regan Meredith, Seeley Apryle, Mariotti Mauro, Youmans Amanda, Polivy Adam, Mandato Lucy, McDermott David, Stanbridge Eric, Atkins Michael
Abstract excerpt
PURPOSE: Similar to other molecularly targeted agents, temsirolimus, an inhibitor of mammalian target of rapamycin, has shown promising activity in advanced renal cell carcinoma. However, only a subset of patients appears to derive significant tumor responses. In an effort to identify potential predictors of response to temsirolimus, tumor samples from a subset of patients within a randomized phase II trial of...
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