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Article

Bulldog dwarfism in Dexter cattle is caused by mutations in ACAN.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Nov 2007

Cavanagh Julie A L, Tammen Imke, Windsor Peter A, Bateman John F, Savarirayan Ravi, Nicholas Frank W, Raadsma Herman W

Abstract excerpt

Bulldog dwarfism in Dexter cattle is one of the earliest single-locus disorders described in animals. Affected fetuses display extreme disproportionate dwarfism, reflecting abnormal cartilage development (chondrodysplasia). Typically, they die around the seventh month of gestation, precipitating a natural abortion. Heterozygotes show a milder form of dwarfism, most noticeably having shorter legs. Homozygosity...

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Source

Identifiers

PMID: 17952705
DOI: 10.1007/s00335-007-9066-9

Genes

ACAN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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