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A CACNA2D2-Related Recessive Form of Cerebellar Abiotrophy in Angus Cattle.

Animal genetics - 1 Apr 2026

Jacinto Joana, Chianini Francesca, Moore Jo, Geraghty Timothy, Häfliger Irene M, Seefried Franz R, Jones Alwyn, Carty Helen, Letko Anna, Drögemüller Cord

Abstract excerpt

Cerebellar disease in ruminants is often virus-induced and non-genetic, but there are also rare inherited forms of cerebellar hypoplasia and cerebellar abiotrophy (CA). So far, no causal variant has been reported for these conditions in cattle. Two inbred Angus calves suspected of having cerebellar disease were reported in Scotland. The aims of this study were to characterize the clinicopathological phenotype of...

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Identifiers

PMID: 41873845
DOI: 10.1002/age.70086
PMCID: PMC13011162

Genes

CACNA2D2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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