Article
Polymorphisms of the uridine-diphosphoglucuronosyltransferase 1A1 gene and coronary artery disease.
Cellular & molecular biology letters - 1 Jan 2008
Hsieh Chia-Jung, Chen Meng-Jung, Liao Yung-Liang, Liao Tung-Nan
Abstract excerpt
Bilirubin, an antioxidant in the blood, plays a role in protection from atherosclerosis. The level of bilirubin is highly correlated to the incidence of coronary artery disease (CAD). Unconjugated bilirubin is conjugated with glucuronic acid through the reaction of uridine 5'-diphosphate-glucuronosyl transferase 1A1 (UGT1A1). The interactions of CAD and the variations in the coding regions of the UGT1A1 gene have...
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