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Article

ubiquilin antagonizes presenilin and promotes neurodegeneration in Drosophila

18 Oct 2007

Abstract excerpt

The majority of familial Alzheimer's disease (AD) cases are caused by mutations in presenilins, therefore, identifying regulators of presenilins is crucial for understanding AD pathogenesis. Ubiquilin 1 (UBQLN1) binds Presenilins in mammalian cells; however, the functional significance of this interaction in vivo remains unclear. Moreover, while genetic variants in UBQLN1 have recently been reported to associate...

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PMID: 17947293
DOI: 10.1093/hmg/ddm305

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