Article
The Epstein-Barr virus BMRF-2 protein facilitates virus attachment to oral epithelial cells.
Virology - 20 Jan 2008
Xiao Jianqiao, Palefsky Joel M, Herrera Rossana, Berline Jennifer, Tugizov Sharof M
Abstract excerpt
We previously reported that BMRF-2, an Epstein-Barr virus (EBV) glycoprotein, binds to beta1 family integrins and is important for EBV infection of polarized oral epithelial cells. To further study the functions of BMRF-2, we constructed a recombinant EBV that lacks BMRF-2 expression by homologous recombination in B95-8 cells. We found that lack of BMRF-2 resulted in about 50% reduction of EBV attachment to oral...
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