Article
Estrogen-induced alterations in amh and dmrt1 expression signal for disruption in male sexual development in the zebrafish.
Environmental science & technology - 1 Sept 2007
Schulz Rudiger W, Bogerd Jan, Male Rune, Ball Jonathan, Fenske Martina, Olsen Lisbeth C, Tyler Charles R
Abstract excerpt
Dmrt1 and amh are genes involved in vertebrate sex differentiation. In this study, we cloned dmrt1 and amh cDNAs in zebrafish (Danio rerio) and investigated the effects of exposure to 17a-ethinylestradiol (EE2), during early life on their patterns of expression and impact on the subsequent gonadal phenotype. Expression of both amh and dmrt1 in embryos was detected as early as at 1 day post fertilization (dpf) and...
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